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|Title:||In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines|
|Author:||Vaz, Josiana A.|
Almeida, Gabriela M.
Vasconcelos, M. Helena
Ferreira, Isabel C.F.R.
|Citation:||Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R. (2010) - In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines. In 2º Encontro Nacional de Química Terapêutica. Porto|
|Abstract:||Some mushrooms are a powerful source of bioactive compounds. lndeed, many pre-clinical studies have been conducted in human tumour cell lines and in some cases a number of compounds extracted from mushrooms have entered clinical trials . Our previous results showed that phenolic (methanolic and ethanolic) and polissacharidic extracts from Clitocybe alexandri inhibited the growth of four human cell lines (lung, breast, colon and gastric cancer) . The aim of the present work was to: i) further elucidate the mechanism of action of the ethanolic extract that leads to the observed cell growth inhibition, by analysing the cell cycle profile of the NCI-H460 cells treated with this extract and ii) identify and quantify the chemical compounds present in the phenolic and polissacharidic extracts.|
|Appears in Collections:||BB - Resumos em Proceedings Não Indexados ao ISI/Scopus|
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