Biblioteca Digital do Instituto Politécnico de Bragança   Instituto Politécnico de Bragança

Biblioteca Digital do IPB >
Escola Superior de Tecnologia e Gestão >
Tecnologia Química e Biológica >
DTQB - Posters em Encontros Científicos Internacionais >

Please use this identifier to cite or link to this item:

Título: Solid-liquid equilibria of some pharmaceutical compounds
Autor: Mota, Fátima
Queimada, António
Pinho, Simão
Macedo, Eugénia A.
Palavras-chave: Pharmaceutical compounds
Issue Date: 2008
Citação: Mota, Fátima; Queimada, António; Pinho, Simão; Macedo, Eugénia (2008) - Solid-liquid equilibria of some pharmaceutical compounds. In XXI Encontro da Sociedade Portuguesa de Química. Porto
Resumo: Solubility is an important property which affects the release, transport and absorption of drugs. Solubility data involving new drug molecules and their precursors are frequently unavailable hampering drug formulation. Although some thermodynamic models can be used, the existence of some experimental data is still fundamental for an appropriate model development and evaluation. In this work, solubilities of some drugs, such as paracetamol, budesonide, allopurinol and flurosemide were measured as a function of the temperature in several solvents, namely water, ethanol and acetone. Solubilities were determined by the analytical shake-flask method, using constant temperature jacketed glass cells for generating the saturated solutions, followed by composition analysis by HPLC. As the analytical shake-flask method is an expensive and time consuming procedure, an alternative method to measure solubility using DSC was also studied [1] with the advantage of being faster and consuming smaller amounts of sample. Melting data of the, pure drugs were also obtained by DSC. The NRTL-SAC model [2j was used to represent the measured data. This model provides a simple and practical thermodynamic framework for phase equilibria of drug systems. A comparison between experimental and model results showed that NRTL-SAC is an appropriate tool to represent the solubility of these complex molecules.
Appears in Collections:DTQB - Posters em Encontros Científicos Internacionais

Files in This Item:

File Description SizeFormat
SPQ2008a.pdf1,41 MBAdobe PDFView/Open

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


© Instituto Politécnico de Bragança - Biblioteca Digital - Feedback - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia