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Título: Temperature and solvent effects in the solubility of some drugs: experimental and modeling
Autor: Queimada, António
Mota, Fátima
Pinho, Simão
Macedo, Eugénia A.
Palavras-chave: Pharmaceutical compounds
Issue Date: 2009
Citação: Queimada, António; Mota, Fátima; Pinho, Simão; Macedo, Eugénia (2009) - Temperature and solvent effects in the solubility of some drugs: experimental and modeling. In VIII Iberoamerican Conference on Phase Equilibria and Fluid Properties for Process Design. Portimão.
Resumo: New drugs are always appearing during the development of new therapies or the improvement of existing ones. The effects of these drugs in the organism are dependent on the techniques used by the pharmaceutical industry to make them more soluble [1]. Solubility data involving new drug candidates are frequently not available in the open literature and, although predictive thermodynamic models can be used, the availability of experimental data is still fundamental for an appropriate model development and evaluation. One of the most recent and successful models is the Nonrandom Two Liquid Segment Activity Coefficient (NRTL-SAC) model [2-5], which gives reasonable results in the prediction of drug solubilities and has been widely applied to correlate and predict phase equilibria of highly nonideal systems, both in pure and mixed systems, both at academic and industrial level.
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