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|Title: ||Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis|
|Authors: ||Lima, R.|
|Keywords: ||Red blood cell|
|Issue Date: ||2009|
|Citation: ||Lima, R.; Nakamura, M.; Omori, T.; Ishikawa, T.; Wada, S.; Yamaguchi, T. (2009) - Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis. In 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing. Advances in Computational Vision and Medical Image Processing: Methods and Applications. [S.l.]: Springer. ISBN 978-1402090851. p.203-220.|
|Abstract: ||Approximately, the half volume of the blood is composed of red blood
cells (RBCs) which is believed to strongly influence its flow properties.
Blood flow in microvessels depends strongly on the motion, deformation
and interaction of RBCs. Several experimental studies on both individual
and concentrated RBCs have already been performed in the past (Goldsmith
1971, Goldsmith and Marlow 1979, Chien et al. 1984, Goldsmith
and Turitto 1986). However, all studies used conventional microscopes
and also ghost cells to obtain visible trace RBCs through the microchannel.
Recently, considerable progress in the development of confocal microscopy
and consequent advantages of this microscope over the conventional
microscopes have led to a new technique known as confocal micro-PIV
(Tanaami et al. 2002, Park et al. 2004, Lima et al. 2006, 2007a). This technique
combines the conventional PIV system with a spinning disk confocal
microscope (SDCM). Due to its outstanding spatial filtering technique together
with the multiple point light illumination system, this technique has
the ability to obtain in-focus images with optical thickness less than 1 mm.
In a numerical context, blood flow in large arteries is usually modeled
as a continuum however this assumption is not valid in small vessels such
as arterioles and capillaries. In this way, we are developing an integrative
multi-scale model to simulate the blood flow at mesoscopic level. This
computational approach may provide important information on the rheology
of blood in small vasculatures where non-Newtonian property of
blood is not negligible.
The main purpose of this paper is to measure flow behavior of individual
RBCs at different haematocrits (Hct) through a 75mm circular polydimethysiloxane
(PDMS) microchannel by means of confocal micro-PTV
system. Moreover we introduce an integrative multi-scale model to simulate
the blood flow behavior through microvessels in order to obtain more
detailed insights about the blood rhelogical properties at cellular level.|
|Appears in Collections:||DTM - Publicações em Proceedings Indexadas ao ISI|
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