Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/1597
Title: Optimization of mobile phase composition for preparative separation of profens enantiomers by chiral liquid chromatography
Author: Ribeiro, António E.
Graça, Nuno S.
Pais, L.S.
Rodrigues, A.E.
Keywords: Mobile phase composition
Preparative liquid chromatography
Chiral separation
Non-steroidal anti-inflammatory drugs
Profens
Issue Date: 2008
Publisher: Universidade do Minho
Citation: Ribeiro, A.; Graça, N.; Pais, L.S.; Rodrigues, A. (2008) - Optimization of mobile phase composition for preparative separation of profens enantiomers by chiral liquid chromatography. In 10th International Chemical and Biological Engineering Conference - CHEMPOR. Braga. ISBN 978-972-97810-3-2
Abstract: In this paper it will be presented and discussed the experimental and simulation results obtained for the preparative separation of ketoprofen and flurbiprofen enantiomers by chiral liquid chromatography. Experimental results include solubility studies, elution and frontal chromatographic experiments and the measurement of competitive adsorption isotherms, using different mobile phase compositions. Modeling and simulation tools are used to predict the behavior and the performance of fixed bed and simulated moving bed processes. These prediction tools are used to select the proper mobile phase composition for the enantiomers separation in a preparative and production-scale point of view.
URI: http://hdl.handle.net/10198/1597
Appears in Collections:DTQB - Artigos em Proceedings Não Indexados ao ISI/Scopus

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