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Title: Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel
Author: Fujiwara, Hiroki
Ishikawa, Takuji
Lima, R.
Matsuki, Noriaki
Imai, Yohsuke
Kaji, H.
Nishizawa, M.
Yamaguchi, Takami
Keywords: Red blood cells
Issue Date: 2009
Publisher: Elsevier
Citation: Fujiwara, H.; Ishikawa, T.; Lima, R.; Matsuki, N.; Imai, Y.; Kaji, H.; Nishizawa, M.; Yamaguchi, T. (2009) - Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel. Journal of Biomechanics. ISSN 0021-9290. 42:7, p.838-843
Abstract: We investigated the behaviour of red blood cells (RBCs) in a micro-channel with stenosis by using a confocal micro-PIV system. We could successfully measure individual trajectories of RBCs in a concentrated suspension up to 20% hematocrit (Hct). The results show that the trajectories of healthy RBCs become asymmetric before and after the stenosis, though trajectories of tracer particles in pure water are almost symmetric. The asymmetry is larger in a 10% Hct case than in a 20% Hct case. We also investigated the effect of deformability of RBCs on the trajectories by hardening RBCs by glutarardehyde treatment. The results indicate that the deformability is the key factor in the asymmetry of trajectories and the thickness of cell-free layer. We think that the present results give fundamental knowledge for better understanding blood flow in microcirculations.
ISSN: 0021-9290
Appears in Collections:DTM - Artigos em Revistas Indexados ao ISI/Scopus

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