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|Título:||The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training|
Leitão, José C.
Silva, António J.
|Editora:||Biomed Central Ltd.|
|Citação:||Pereira, Ana; Costa, Ana; Leitão José C.; Monteiro, A.M.; Izquierdo, Mikel; Silva, A.J.; Bastos, Estela; Marques, Mário C. (2013). The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training. BMC Geriatrics. ISSN 1471-2318. 13:1|
|Relatório da Série N.º:||1;131|
|Resumo:||Background:We studied the influence of the ACE I/D and ACTN3 R577X polymorphisms (single or combined) onlower-extremity function in older women in response to high-speed power training.Methods:One hundred and thirty-nine healthy older Caucasian women participated in this study (age: 65.5 ± 8.2 years,body mass: 67.0 ± 10.0 kg and height: 1.57 ± 0.06 m). Walking speed (S10) performance and functional capacityassessed by the“get-up and go”(GUG) mobility test were measured at baseline (T1) and after a consecutive 12-weekperiod of high-speed power training (40-75% of one repetition maximum in arm and leg extensor exercises; 3 sets4–12 reps, and two power exercises for upper and lower extremity). Genomic DNA was extracted from blood samples,and genotyping analyses were performed by PCR methods. Genotype distributions between groups were comparedby Chi-Square test and the gains in physical performance were analyzed by two-way, repeated-measures ANOVA.Results:There were no significant differences between genotype groups in men or women for adjusted baselinephenotypes (P > 0.05). ACE I/D and ACTN3 polymorphisms showed a significant interaction genotype-training only inS10 (P = 0.012 and P = 0.044, respectively) and not in the GUG test (P = 0.311 and P = 0.477, respectively). Analyses ofthe combined effects between genotypes showed no other significant differences in all phenotypes (P < 0.05) atbaseline. However, in response to high-speed power training, a significant interaction on walking speed (P = 0.048)was observed between the“power”(ACTN3 RR + RX & ACE DD) versus“non-power”muscularity-oriented genotypes(ACTN3 XX & ACE II + ID)].Conclusions:Thus, ACE I/D and ACTN3 R577X polymorphisms are likely candidates in the modulation ofexercise-related gait speed phenotype in older women but not a significant influence in mobility traits. The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training. Available from: https://www.researchgate.net/publication/259244416_The_influence_of_ACE_ID_and_ACTN3_R577X_polymorphisms_on_lower-extremity_function_in_older_women_in_response_to_high-speed_power_training [accessed Nov 17, 2015].|
|Aparece nas colecções:||ESE - Artigos em Revistas Indexados à WoS/Scopus|
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