Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/12032
Título: New insights on the effects of formulation type and compositional mixtures over the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plants
Autor: Pereira, Carla
Barreira, João C.M.
Calhelha, Ricardo C.
Queiroz, Maria João R.P.
Barros, Lillian
Ferreira, Isabel C.F.R.
Palavras-chave: Dietary supplements
Formulation
Compositional mixture
Bioactivity
Citotoxicity
Synergism
Data: 2014
Editora: Royal Society of Chemistry
Citação: Pereira, Carla; Barreira, João C.M.; Calhelha, Ricardo C.; Queiroz, Maria João R.P.; Barros, Lillian; Ferreira, Isabel C.F.R. (2014) - New insights into the effects of formulation type and compositional mixtures over the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plants. Food & Function. ISSN 2042-6496. 5:9, p. 2052-2060
Resumo: Artichoke (A), borututu (B) and milk thistle (M) are included in several supplements to provide beneficial effects. Different formulations (infusions, pills and syrups), as also different proportions of A, B and M (1:1:1, 2:1:1, 1:2:1, 1:1:2) within each formulation were assayed to optimize the desired benefits. The antioxidant activity, anti-hepatocellular carcinoma activity, hepatotoxicity and bioactive compounds contents were evaluated. Syrups tended to be the formulation with highest antioxidant activity and total phenolics and flavonoids content; otherwise, pills were the worst formulation. In what concerns A:B:M ratios, the results did not reveal so pronounced differences. None of the assayed mixtures resulted to be toxic (up to the maximum assayed dose) for liver primary cells (PLP2), but some samples, especially infusions, showed toxicity for the hepatocellular carcinoma cell line (HepG2). With no exception, the mixtures for all formulations gave synergistic effects in antioxidant activity, when compared to the activity of single plants.
Peer review: yes
URI: http://hdl.handle.net/10198/12032
DOI: 10.1039/c4fo00387j
ISSN: 2042-6496
Aparece nas colecções:CIMO - Artigos em Revistas Indexados à WoS/Scopus

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