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Title: Design of SMB chiral separations using the concept of separation volume
Authors: Rodrigues, A.E.
Pais, L.S.
Keywords: Separation volume
Simulated moving bed
Chiral separation
Numerical simulation
Issue Date: 2004
Publisher: Taylor & Francis
Citation: Rodrigues, A.E.; Pais, L.S. (2004) - Design of SMB chiral separations using the concept of separation volume. Separation Science and Technology. ISSN 1520-5754. 39:2, p.245-270
Abstract: The article deals with chiral separation by simulated moving bed (SMB) chromatography. When mass transfer resistances are negligible, equilibrium theory provides explicit criteria for the choice of the SMB operating conditions. However, in the presence of mass transfer resistances, the SMB operating conditions should be evaluated through simulation. Using a package based on the analogy with the true moving bed operation, this work shows how mass transfer resistance can affect the conditions for enantiomers separation, as well as the critical values stated by equilibrium theory. The concept of separation volume is applied to show how the flow-rate constraints, in presence of mass transfer resistances, have to be modified for chiral separations in which the adsorption equilibrium isotherms of both enantiomers are of linear + Langmuir type.
Peer review: yes
ISSN: 1520-5754
Publisher Version:
Appears in Collections:DTQB - Artigos em Revistas Indexados ao ISI/Scopus

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