Biblioteca Digital do Instituto Politécnico de Bragança   Instituto Politécnico de Bragança

Biblioteca Digital do IPB >
Escola Superior de Tecnologia e Gestão >
Tecnologia Química e Biológica >
DTQB - Artigos em Revistas Indexados ao ISI/Scopus >

Please use this identifier to cite or link to this item:

Título: Enantiomers separation by simulated moving bed chromatography. Non-instantaneous equilibrium at the solid-fluid interface
Autor: Azevedo, D.C.S.
Pais, L.S.
Rodrigues, A.E.
Palavras-chave: Enantiomer separation
Simulated moving bed chromatography
Adsorption kinetics
Non-linear chromatography
Non-equilibrium effects
Issue Date: 1999
Editora: Elsevier
Citação: Azevedo, D.C.S.; Pais, L.S.; Rodrigues, A.E. (1999) - Enantiomers separation by simulated moving bed chromatography. Non-instantaneous equilibrium at the solid-fluid interface. In Journal of Chromatography A. ISSN 0021-9673. 865:1-2, p.187-200
Resumo: The simulated moving bed (SMB) technology, first conceived for large bulk-scale separations in the petrochemical industry, has found increasingly new applications in the pharmaceutical industry. Among these, the separation of fine chemicals has been the subject of considerable study and research. This work presents the modeling, simulation and design of the operation of a SMB plant in order to separate a binary chiral mixture. The usual assumption of instantaneous equilibrium at the solid–fluid interface is questioned and a first-order kinetics of adsorption is taken into account. The cases of linear, Langmuir and modified Langmuir equilibria are studied. The equivalent true moving bed (TMB) model was used assuming axial dispersion for the fluid flow and plug flow for the solid-phase flow. Intraparticle diffusion was described by a linear driving force (LDF) approximation. Simulation results indicate that, under certain conditions, equilibrium is not actually reached at the adsorbent surface. This leads to different unit performances, in terms of product purities and recoveries, as compared to those predicted assuming instantaneous equilibrium. Moreover, SMB units may be improperly designed by the usual methods (flow-rate ratio separation regions) if non-equilibrium effects are overlooked.
Arbitragem científica: yes
ISSN: 0021-9673
Versão do Editor:
Appears in Collections:DTQB - Artigos em Revistas Indexados ao ISI/Scopus

Files in This Item:

File Description SizeFormat
06. 1999 JCA.pdf636,54 kBAdobe PDFView/Open

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


© Instituto Politécnico de Bragança - Biblioteca Digital - Feedback - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia