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Title: Modeling strategies for enantiomers separation by SMB chromatography
Authors: Pais, L.S.
Loureiro, José M.
Rodrigues, A.E.
Keywords: Simulated moving bed chromatography
Modeling and Simulation
Chiral separation
Issue Date: 1998
Publisher: Wiley
Citation: Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (1998) - Modeling strategies for enantiomers separation by SMB chromatography. AIChE Journal. ISSN 1547-5905. 44:3, p.561-569
Abstract: Modeling strategies for simulated moving bed adsorbers were studied to compare the simulated moving bed model (SMB) that considers the real shift of the injection and collection points to the true moving bed approach (TMB) that considers liquid and solid flow in opposite directions. The prediction of these two models is compared in terms of steady-state performance, steady-state internal concentration profiles, and transient behavior of the extract and raffinate purities. The influence of the degree of subdivision of the bed in the SMB model predictions is also analyzed and compared with the TMB performance. Model results are compared with experimental results obtained for the chromatographic separation of binaphthol enantiomers.
Peer review: yes
ISSN: 1547-5905
Publisher Version:
Appears in Collections:DTQB - Artigos em Revistas Indexados ao ISI/Scopus

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