Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/11480
Título: Mentha aquatica L. extract effects on mitochondrial bioenergetics
Autor: Ferreira, Fernanda M.
Pereira, Olívia R.
Cardoso, Susana M.
Oliveira, Paulo J.
Moreno, António J.M.
Palavras-chave: Mentha aquatica L.
Mitochondria bioenergetics
Oxidative phosphorylation
Data: 2014
Editora: Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biologia
Citação: Ferreira, Fernanda M.; Pereira, Olívia R.; Cardoso, Susana M.; Oliveira, Paulo J.; Moreno, António J.M. (2014). Mentha aquatica L. extract effects on mitochondrial bioenergetics. In 18th European Bioenergetics Conference. Lisboa
Resumo: Mentha aquatica (water mint) extracts are regularly used in food flavoring and pharmacology. In the present study, the possible effects of an ethanolic extract from leaves of M. aquatica L. on rat liver mitochondria bioenergetics were evaluated. The plant extract (25 μg·mg protein−1) but not the vehicle, inhibited the mitochondrial oxidative system, as seen by a depression of respiration (state 3, respiratory control ratio (RCR), FCCP stimulated respiration) and lower generation of the transmembrane electric potential using glutamate+malate and succinate as respiratory substrates. The depressing effects in oxidative phosphorylation can probably be related with the polyphenolic composition of the extract (mainly eriodictyol-7-O-rutinoside, luteolin-7-O-rutinoside, naringenin- 7-O-rutinoside, hesperitin-7-O-rutinoside and rosmarinic acid) that can interact with membrane and change the inner mitochondrial membrane lipidic moiety. Despite decreasing the RCR, the presence of M. aquatica extract did not affect the mitochondrial phosphorylative capacity, as estimated by the ADP/O ratio. No significant increase in inner mitochondrial membrane permeability was observed and induction of mitochondrial permeability transition pore was not altered in the range of concentrations tested (up to 25 μg·mg protein−1) either. For the highest concentrations tested (25 μg·mg protein−1 or higher) the inhibition observed on the mitochondrial respiratory chain, as reflected by FCCP-stimulated respiration, revealed that M. aquatica ethanolic extract is toxic for mitochondrial bioenergetics. In conclusion, the presente study suggests that a high daily consumption of an ethanolic extract of M. aquatica leaves should be regarded as hazardous.
Peer review: yes
URI: http://hdl.handle.net/10198/11480
Versão do Editor: http://www.ebec2014.org/
Aparece nas colecções:CIMO - Posters em Encontros Científicos Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
poster Q2013 mentha final.pdf2,22 MBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.