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Advisor(s)
Abstract(s)
Dietary phenolic compounds are widely considered to contribute to health benefits in humans. However,
little is known about their bioactive forms in vivo and the mechanisms by which they may contribute
toward disease prevention. Moreover, many studies on the biological effects of phenolic compounds have
ignored the question of their achievable concentrations in the circulation after ingestion as well as their
metabolism [1].
Wild mushrooms are extensively studied due to their medicinal properties which have been related to the
presence of bioactive molecules such as phenolic compounds. p-Hydroxibenzoic acid is among the most
abundant phenolic acids found in wild mushrooms, as well as cinnamic acid [2].
The present work aims at contributing to the knowledge of the mechanisms involved in the healthpromoting
properties of phenolic acids and precursors, usually present in mushrooms.
Herein, we describe the synthesis of acetylated glucuronide derivatives of p-hydroxybenzoic and cinnamic
acids, as protected glucuronide metabolites (Scheme).
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Pedagogical Context
Citation
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Martins, Anabela; Esteves, Ana P.; Queiroz, Maria João R. P. (2013). Synthesis of acetylated glucuronide derivatives of p-hydroxybenzoic and cinnamic acids, two compounds commonly found in wild mushrooms. In In 1st International Symposium on Profiling. Almada. ISBN 978-989-98415-5-0