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Orientador(es)
Resumo(s)
This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation.
Descrição
Palavras-chave
Nadolol Chiral separation Mobile phase composition Simulated moving red
Contexto Educativo
Citação
Ribeiro, António E.; Pais, L. S.; Rodrigues, Alírio E. (2012). Chiral separation of nadolol stereoisomers by liquid chromatography : screening of mobile phase composition and SMB separation. In ANQUE's International Congress of Chemical Engineering (ANQUE-ICCE 2012. Sevilla, Spain