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Advisor(s)
Abstract(s)
In this work we pretend to clear demonstrate that the choice of the proper solvent is crucial for both analytical and preparative separations. The work developed in the last years by the LSRE group will be described with three real optimization case-studies: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofeno enantiomers) and one antihypertensive drug (the separation of nadolol stereoisomers).
Description
Keywords
Mobile phase composition Preparative chromatography Simulated moving-bed
Citation
Ribeiro, António E.; Graça, Nuno S.; Gomes, P. Sá; Pais, L. S.; Rodrigues, Alírio E. (2012). Choosing the right solvent for preparative liquid chromatography. In 7º Encontro Nacional de Cromatografia, Sociedade Portuguesa de Química. Universidade do Porto, Porto, Portugal