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Advisor(s)
Abstract(s)
The work presents modelling, simulation and experimental results for the chiral separation of non-steroidal anti-inflammatory drugs, particularly, the optimization of mobile phase composition under preparative and simulated moving bed chromatography. The experimental separation of two chiral systems (ketoprofen and flurbiprofen enantiomers) will be presented to show how compounds of the same family can lead to different solutions.
Description
Keywords
Simulated moving bed chromatography Solvent composition Non-steroidal anti- inflammatory drugs Preparative chiral separation
Citation
Ribeiro, António E. Gomes, Pedro Sá Pais, L. S. Rodrigues, Alírio E. (2011). Chiral separation of non-steroidal anti-inflammatory drugs by preparative and simulated moving bed chromatography. In CHEMPOR 2011 11th International Chemical and Biological Engineering Conference. Lisboa, Portugal