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Ganoderma lucidumis one of the most famous traditional medicinal mushrooms, being used as
functional food and in preventive medicines [1 ]. p-Hydroxybenzoic and cinnamic acids were
previously identified, by our research group, in wild G. lucidum from Northeast of Portugal
[2].Many studies suggest that phenolic compounds are rapidly metabolized in the human
organism being glucuronidation the most prevalent metabolic pathway for phenolic compounds in
humans. Despite the large data concerning the antimicrobial effects of phenolic acids [3], studies
dealing with the antimicrobial properties of their metabolites or derivatives are scarce due to the
fact that most of these compounds are not commercially available. Herein we describe the
synthesis of protected (acetylated) glucuronide derivatives of p-hydroxybenzoic and cinnamic
acids. Their antimicrobial activity was evaluated and compared to the parent acids and G.
lucidum extract.p-Hydroxybenzoic and cinnamic acids, as also their protected glucuronide
derivatives revealed high antimicrobial (antibacterial and antifungal) activity, even better than the
one showed by commercial standards. Despite the variation in the order of parent acids and the
protected glucuronide derivatives, their antimicrobial activity was always higher than the one
revealed by the extract. The synthesized acetylated glucuronide derivatives could be deprotected
to obtain glucuronide metabolites, which circulate in the human organism as products of the metabolism of the parent compounds.
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Heleno, S.A.; Ferreira, I.C.F.R.; Esteves, A.P.; Ćirić, A.; Glamočlija, J.; Martins, A.; Soković, M.; Queiroz, M. J. R. P. (2013). Antimicrobial activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters. In 1st Symposium on Medicinal Chemistry. Braga