| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 436.26 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Angiogenesis, the growth of new vessels from preexisting vasculature, is a critical step in tumor
progression [1]. The tyrosine kinase Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is
a crucial mediator in angiogenesis since the VEGF, excreted by the tumor cells, binds to it
activating several signaling pathways involved in cell survival and proliferation [2]. Recently
thienopyridine derivatives showed to be promising inhibitors of the tyrosine kinase domain of
VEGFR2 [3,4]. In this work new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides were
prepared as potential VEGFR2 inhibitors suggested by rational design, as presented below.
Descrição
Palavras-chave
Contexto Educativo
Citação
Campos, Joana F.; Begouin, Agathe; Peixoto, Daniela; Froufe, Hugo J.C.; Abeu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P. (2013). Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2. In 1st Symposium on Medicinal Chemistry. Braga