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Radical scavenging activity, lipid peroxidation inhibition and redox profile of aminodiarylamines in the thieno[3,2-b]pyridine series

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The reducing properties of diarylamines make them very important as antioxidants, especially as radical scavengers as it has been demonstrated by our and other research groups [1 -3]. Three di(hetero)arylamines were prepared by C- N coupling of the methyl3-amino-6-bromothieno(3,2- b]pyridine-2-carboxylate with bromonitrobenzenes and further reduced to the amino compounds 1a-c (Scheme) (4].

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Calhelha, Ricardo C.; Vilas-Boas, Miguel; Queiroz, Maria-João R. P.; Ferreira, Isabel C.F.R. (2013). Radical scavenging activity, lipid peroxidation inhibition and redox profile of aminodiarylamines in the thieno[3,2-b]pyridine series. In 1st Symposium on Medicinal Chemistry. Braga

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