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Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine séries. In 1st Symposium on Medicinal Chemistry. Braga
Several thienopyridines have already been described as inhibitors of cell proliferation using
human tumor cells[1,2], highlighting the interest of studying their antitumorpotential. ln this work,
we present the synthesis of di(hetero)arylthioethers 1a-fby SNAr of the 7-chloro thieno[3,2-
b]pyridine with amino or methoxy thiophenols in good to high yields, like presented in the scheme.
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Calhelha, Ricardo C.; Campos, Joana; Peixoto, Daniela; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P. (2013). Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine séries. In 1st Symposium on Medicinal Chemistry. Braga