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Tetrahydroquinazoline-substituted chromones from Diels–Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane

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Tetrahedron Lett 2012, 53, 2722.pdf549.46 KBAdobe PDF Ver/Abrir
1-s2.0-S0040403912004960-main.pdf407.79 KBAdobe PDF Ver/Abrir

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Resumo(s)

The Diels-Alder reaction of (E)-2-styrylchromones with a pyrimidine ortho-quinodimethane is reported for the first time. These cycloaddition reactions afford mixtures of two regioisomeric tetrahydroquinazoline-substituted chromones in moderate to excellent global yields. Irrespectively of the substituents on the 2-styrylchromones, the 2-(7-aryl-4-methoxy-2-methyl-5,6,7,8-tetrahydroquinazolin-6-yl)chromone derivatives are always the major isomers.

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Palavras-chave

Tetrahydroquinazolines Cycloadditions 2-Styrylchromones Pyrimidine ortho-Quinodimethane NMR

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Elsevier

Licença CC

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