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Chromones and xanthones are two classes of oxygenated heterocyclic compounds
widely distributed in natureY1 Both natural and synthetic derivatives have been reported to
exhibit biological, pharmacological and biocidal properties.11.21 The antioxidant capacity
deserves a special mention and the structure-activity studies indicate that a substitution
pattern that includes the presence of phenolic and/or catecholic moieties is highly
important. 131
Inspired by the chemical structures of natural products we developed new routes for
the synthesis of the quite rare family of 2-styrylchromones 1 and challenged us to design
novel bioactive derivatives. 141 The reactivity of 3-bromo-2-styrylchromones was explored
for the synthesis of unique examples of 2,3-diarylxanthones 2.151 Moreover, we focus our
attention in the potential value of the hydroxylated 2-styrylchromones and -xanthones in
order to establish structure-antioxidant activity relationships. 161
Highlights of our efforts towards the synthesis, spectroscopic characterization and
antioxidant profile of chromones 1 and xanthones 2 and of all the intermediates will be
presented and discussed.
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Santos, Clementina M. M.; Silva, Artur; Pinto, Diana; Cavaleiro, José (2012). Polyhydroxylated 2-styrylchromones and –xanthones as potent antioxidante agentes. In Natural Products and related Redox Catalysts. Aveiro