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Advisor(s)
Abstract(s)
Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[
b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C–N coupling
methodology. The minimal inhibitory concentration (MIC) and structure–activity relationships (SARs) were evaluated.
Description
Keywords
Diarylamines Antimicrobial activity SAR Benzothiophenes
Pedagogical Context
Citation
Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Estevinho, Leticia M.; Queiroz, Maria João R.P. (2004). Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: A structure-activity evaluation study. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 14:23, p. 5831-5833
Publisher
Elsevier