Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines

Calhelha, Ricardo C.; Peixoto, Daniela; Soares, Pedro; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.

http://hdl.handle.net/10198/7834

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Authors

Ferreira, Isabel C.F.R.

Queiroz, Maria João R.P.

Abstract(s)

Thienopyridine skeleton has been reported as havi ng inte resting biological activity, namely antitumorlll and antiangiogenic121 activities. Herein, we describe the synth esis of thienopyridine arylethers la-f in moderate to good yields by a copper-cata lyzed C- 0 coupling, using N,N-dimethylglycine as a ligand, of the 7-bromothieno[3,2-b]pyridine, also prepared with substituted phenols (see scheme).

URI

http://hdl.handle.net/10198/7834

Citation

Calhelha, Ricardo C.; Peixoto, Daniela; Soares, Pedro; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P. (2012). Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines. In XXIInd International Symposium on Medicinal Chemistry. Berlin