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Abstract(s)
It has been suggested that exercise has a positive
impact on the prevention and progression of cardiovascular
disease (CVD). One of the main mechanisms is through the
modification of lipoprotein levels and the risk of its
oxidation, especially LDL lipoproteins. After menopause,
women experience an increased incidence of cardiovascular
disease. In contrast, women receiving hormonal replacement
therapy (HRT) seem to be protected. The aim of this
study was to infer how HRT affect lipid peroxidation levels
in postmenopausal women with different levels of aerobic
fitness.
Design & Method: Sixty four women participate in this
study, 32 of them receive HRT (group with HRT –
GWHRT) (average age¼55.9 years, average weight¼
66.9 kg and average high¼156.0 cm) and the remained
32 women didn’t receive HRT (group without HRT –
GWOHRT) (average age¼61.0 years, average weight¼
67.6 kg and average high¼154.3 cm). Total cholesterol
(mg dL71), HDL-cholesterol (mg dL71), LDL-cholesterol
(mg dL71) and triglycerides levels (mg dL71) have been
analyzed in serum obtained from a blood sample collected
after 8 hours of fasting, and measured in Dr. Lange LP20
according to the specific manufacturer instructions. Serum
MDA concentration (ng L71) was determined by spectrophotometric
method. Aerobic capacity (VO2max ml
kg71 min71) was assessed according to an adaptation of
Bruce protocol. Differences between groups were tested
through Student t-test. A Spearman correlation was
performed in order to test variables associations. Significance
level was established at 5%.Results: Our results have found differences between groups
in age (t¼3.018; p50.01), in VO2max (t¼73.774;
p50.01) and in serum MDA concentration (t¼6.750;
p50.01). The GWHRT were younger, had a higher
VO2max (31.38 for GWHRT and 26.19 for GWOHRT),
and had lower levels of serum MDA concentration (0.29
for GWHRT and 0.73 for GWOHRT) comparatively with
those women from the GWOHRT. However, our results
failed to find any differences between groups regarding
serum triglycerides, total cholesterol, HDL-cholesterol,
LDL-cholesterol or BMI. In this study, serum MDA
concentration didn’t correlate with higher levels of lipid
profile, as we might have expected, but correlate inversely
with HRT (r¼7.726, p¼.00) and with VO2max
(r¼7.287, p¼.02).
Conclusion: Our results suggest that HRT should exert an
antioxidant protective effect against lipid peroxidation, as
well as exercise perhaps through the stimulation of
antioxidant capacity.
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Citation
Mota, M.P.; Soares, J; Moreira, M.H.; Leitão, J.C.; Freitas, Joana Isabel Martins; Monteiro, A.M.; Figueiredo, P.; Duarte, J.A. (2008). Influence of hormonal replacement therapy in lipid peroxidation levels of postmenopausal women with different cardiovascular capacity. In 12th World Congress on the Menopause e Climacteric: The Journal Of The International Menopause Society. ISSN 1473-0804. Vol. 11, Suppl 2, p. 204