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Publication
Flow of red blood cells through microchannel with a confluence
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Advisor(s)
Abstract(s)
Over the years micro-visualization techniques have been used to investigate in vitro blood flow through straight microchannels with dimensions close to in vivo capillaries. However, a few detailed studies have been performed in complex in vitro microvascular networks composed by diverging and converging bifurcations. The main purpose of present work is to show the application of a confocal micro-PTV system to track both flourescent particles and red blood cells (RBCs) through a rectangular polydimethysiloxane (PDMS) microchannel with a confluence. The measurements of the flow behaviour of trace particles suspended in pure water and RBCs in concentrated suspensions were performed in the surroundings of a confluence. After performing simulations with the commercial finite element software package POLYFLOW®, some experimental results were compared with the numerical ones. Experimental results for pure water were in a good agreement with numerical results. Overall, the RBCs velocities were higher than those for fluorescent particles which suggest that RBC deformability and cell-free layer formation around the apex of the confluence may play an important role on the observed deviations
Description
Keywords
Red blood cells Velocity profiles Confocal micro-PTV Confluence Microchannel
Pedagogical Context
Citation
Vladimir, Leble; Lima, R.; Fernandes, Carla S.; Dias, Ricardo P. (2011). Flow of red blood cells through microchannel with a confluence. In Congress on Numerical Methods in Engineering 2011. Coimbra