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Advisor(s)
Abstract(s)
This work presents the experimental and simulation results obtained for the optimization of the mobile
phase composition for the preparative separation of flurbiprofen enantiomers by liquid chromatography
using an amylose-based chiral stationary phase (Chiralpak AD). The experimental work carried out
includes solubility and adsorption isotherm measurements and pulse and breakthrough experiments
under preparative conditions. The simulation work predicts the operation of a simulated moving bed
(SMB) system for the separation of flurbiprofen enantiomers to compare the productivity and solvent
consumption performances, for the different mobile phase compositions and using the experimental data
obtained. This paper presents a new and different case study (flurbiprofen) of the one recently reported
by the authors (ketoprofen enantiomers [A. Ribeiro, N. Grac¸ a, L. Pais, A. Rodrigues, Preparative separation
of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive
adsorption isotherms, Sep. Purif. Technol. 61 (2008) 375–383]), to clearly show that the optimization of
the mobile phase composition for preparative chiral separation requires an individualized study, since
different results are obtained even for enantiomers systems of the same family.
Description
Keywords
Flurbiprofen Enantiomer separation Mobile phase composition Preparative chromatography Simulated moving bed
Citation
Ribeiro, António E.; Graça, Nuno S.; Pais, L. S.; Rodrigues, Alírio E. (2009). Optimization of the mobile phase composition for preparative chiral separation of flurbiprofen enantiomers. Separation and Purification Technology. ISSN 1383-5866. 68, p.9-23
Publisher
Elsevier