Influence of mobile phase composition on the preparative separation of profens by chiral liquid chromatography

Ribeiro, António E.; Pais, Luís S.; Rodrigues, Alírio

http://hdl.handle.net/10198/6366

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Authors

Ribeiro, António E.

Pais, Luís S.

Rodrigues, Alírio

Abstract(s)

The chirality of drugs is an important issue for the pharmaceutical industry, since the different enantiomers of a racemic drug may have distinct pharmacological activities, pharmacokinetic and pharmacodynamic effects. Because of its chiral selectivity, human body reacts with a racemic drug differently, and metabolise each enantiomer on separate pathways producing different pharmacological activity. Thus, one isomer may produce the desired therapeutic activities, while the other may be inactive or even, in worst cases, produce unwanted effects.

URI

http://hdl.handle.net/10198/6366

Citation

Ribeiro, A.E.; Pais, L.S.; Rodrigues, A. (2005). Influence of mobile phase composition on the preparative separation of profens by chiral liquid chromatography. In in ChemPor/05 9th Interantional Engineering Conference. Coimbra.