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Tissue-specific responses against oxidative
stress and lipid peroxidation were analyzed in wild adult
mullet (Liza saliens) caught in the Portuguese coastal
lagoon Esmoriz-Paramos. Parameters measured were catalase
(CAT), superoxide dismutase (SOD), and glutathione-
S-transferase (GST) activities in liver and gill tissues and
lipid peroxidation. The enzyme activities were related to
gill histopathological alterations, as well as to heavy metals
(Cu and Zn) concentrations in these tissues. Gill epithelium
of L. saliens showed histological alterations, such as epithelial
hyperplasia resulting in lamellar fusion, epithelial
lifting, vasodilatation, and lamellar aneurisms, with a
prevalence ranging from 62% to 92%. The highest Cu
content was found in liver (379 mg kg-1), while the highest
Zn content was observed in gill (119 mg kg-1). SOD and
CAT activities showed differences between gill and liver.
The highest activities found were SOD in gill (10.1 U/mg
protein) and CAT in liver (39.2 mmol/min/mg protein). In
gill, CAT activity was negatively related to both Cu levels
and gill lifting, while a positive relationship was found
between SOD activity and fish age. The positive relationship
between Cu and CAT activity in liver suggests that an
increase in metabolic level is related to Cu-induced oxidative
stress. The decrease in gill CAT activity can be due to
osmotic stress caused by damaged gill epithelium. CAT
activity in liver is an appropriate biomarker of oxidative
stress in the Esmoriz-Paramos lagoon.
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Citação
Fernandes, Conceição; Fontaínhas-Fernandes, A.; Ferreira, M.; Salgado, M.A. (2008). Oxidative stress response in gill and liver of Liza saliens, from the Esmoriz-Paramos coastal lagoon, Portugal. Archives Environmental, Contamination and Toxicology. ISSN 0090-4341. 55:2, p. 262-269
Editora
Springer Science