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Antifungal activity of diarylamines in the benzo[b]thiophene series and SAR

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Several diarylamines la-f and 2 were prepared using palladium-catalyzed C-N coupling of electron deficient or rich benzo[b]thienylbromides with aromatic amines. Using 2-aminopyridine a one pot C-N coupling and intermolecular cyclization involving the nitrogen of the pyridine, with lost of ethanol, occurred giving compound 3.

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Calhelha, Ricardo; Ferreira, Isabel C.F.R.; Barbosa, Sandra; Estevinho, Letícia; Queiroz, Maria-João R.P. (2004). Antifungal activity of diarylamines in the benzo[b]thiophene series and SAR. In XII Jornadas de Biologia de Leveduras “Prof. Nicolau van Uden”. Aveiro

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