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Advisor(s)
Abstract(s)
Chromones represent an important class of compounds due to their
broad range of applications. Certain natural and synthetic hydroxyl
derivatives have shown important pharmacological, biocidal and mainly
antioxidant activities.1
We are interested in the design of new 2-styrylchromones analogues
containing hydroxyl groups at the C-3 and Cα=Cβ systems because they
could increase the antioxidation activity of these compounds.2
Our first approach is the preparation of epoxide systems and then we
intend to open the epoxide ring to give the desired hydroxyl derivatives. We studied the epoxidation of 2-styrylchromones 1 with hydrogen
peroxide and iodosylbenzene using N,N'-bis(3,5-di-tert-butylsalicylidine)-
1,2-cyclohexanediaminomanganese (III) chloride [salen Mn(III)] as catalyst.
Different experimental conditions have been used in order to prepare
epoxide compounds 2 in moderate yields.
We report here the synthetic details and structural characterisation of
the obtained epoxides.
Description
Keywords
Citation
Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José (2003). Epoxidation studies do 2-Styrylchromones. In 5º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Japonês. Aveiro