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Advisor(s)
Abstract(s)
In this work, pure solvent solubilities of drugs, such as paracetamol, allopurinol, furosemide and budesonide,
measured in the temperature range between 298.2–315.2K are presented. The solvents under study
were water, ethanol, acetone, ethyl acetate, carbon tetrachloride and n-hexane. Measurements were performed
using the shake-flask method for generating the saturated solutions followed by compositional
analysis by HPLC. Previous literature values on the solubilities of paracetamol were used to assess the
experimental methodology employed in this work. No literature data was found for any of the other
drugs studied in this assay. Melting properties of the pure drugs were also determined by differential
scanning calorimetry (DSC) to provide a broader knowledge about the solubilization process and also for
modeling purposes.
The solubility data as a function of temperaturewere used to determine the thermodynamic properties
of dissolution like, Gibbs energy, enthalpy and entropy. Theoretical work was essentially focused on the
evaluation of theNonrandomTwo-Liquid Segment Activity Coefficient (NRTL-SAC) model, which has been
referred as a simple and practical thermodynamic framework for drug solubility estimation. A satisfactory
agreement was found between experimental and calculated values: the absolute average deviation was
68% for the correlation in the organic solvents and 38% for the prediction in water, where the best results
in prediction could be related to the selected solvents.
Description
Keywords
Drugs Solubility Measurement NRTL-SAC Reference solvent Approach
Citation
Mota, Fátima; Carneiro, Aristides; Queimada, António; Pinho, Simão; Macedo, Eugénia (2009). Temperature and solvent effects in the solubility of some pharmaceutical compounds: measurements and modeling. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 37:3-4 p.499-507
Publisher
Elsevier