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Advisor(s)
Abstract(s)
Blood flow in a microchannel with complex geometries has been
investigated to develop biomedical microdevices (e.g. Faivre et al.,
2006) or to understand pathology in small vessels, such as lacunar
infarcts. In a small channel, say 100 μm in diameter, the blood is no
longer assumed to be a homogeneous fluid because the size of the red
blood cells (RBCs) cannot be neglected compared to the generated
flow field (the diameter of a RBC is about 8 μm). In such a case, we
must treat the blood as a multiphase fluid, and investigate the motion
of individual cells in discussing the flow field. In this study, we
investigated the motion of RBCs in a microchannel with stenosis or
bifurcation using a confocal micro-PTV system. We measured
individual trajectories of RBCs under high Hct conditions (up to 20%),
when the interactions between RBCs become significant. We discuss
the effect of Hct on the flow field and cell-free layers, as well as the
effect of deformability of RBCs on the cell-free layer thickness by
hardening RBCs using a glutaraldehyde treatment.
Description
Keywords
Red blood cell Microcirculation
Citation
Ishikawa, T.; Fujiwara, H.; Matsuki, N.; Lima, R.; Imai, Y.; Ueno, H.; Yamaguchi, T.(2009) - Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries. Proceeding of the ASME. Orlando, USA.