Advisor(s)
Abstract(s)
© 2017 Elsevier Ltd The synthesis of several aminosquaraine cationic dyes displaying strong absorption within the so-called phototherapeutic window (650–850 nm) is described. Their cytotoxicity, under dark and illuminated conditions, was tested against several human tumor cell lines (breast, lung, cervical and hepatocellular carcinomas) and non-tumor porcine liver primary cells. All compounds showed to inhibit the growth of the tumor cells upon irradiation more than in the absence of light, in more or less extension, clearly exhibiting photodynamic activity. The photosensitizing ability against some cell lines, together with the low toxicity for the non-tumor primary PLP2 cells displayed by some of the compounds synthetized, turns them into potential candidates as photosensitizers for PDT.
Description
Keywords
Cancer Photodynamic therapy Photosensitizer Squaraine dyes
Citation
Magalhães, F.; Graça, Vânia C.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Santos, Paulo F. (2017). Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity. Bioorganic and Medicinal Chemistry Letters. ISSN 0960-894X. 27, p. 4467-4470