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Advisor(s)
Abstract(s)
Molecularly imprinted polymer (MIP) particles are here developed to target phenolic compounds present
in mixtures resulting from supercritical extraction processes. Engineered MIP particles are synthetized
considering different polymerization processes to tailor products morphology (e.g. precipitation or
inverse-suspension polymerization to obtain micro-particles [1]) and also diverse functional monomers to
explore preferential interactions with the template polyphenols (e.g. polydatin, resveratrol, etc). Moreover,
MIP particles with surface grafted functional polymer chains (e.g. using RAFT polymerization [2,3]) are
produced to assess the improvement of the selectivity of MIPs towards the target polyphenols, namely
through the tuning of the hydrophilic/hydrophobic effects (amphiphilic materials are generated). The
produced MIP particles are applied for the identification, separation and concentration of phenolic
compounds present in vegetable extracts. Different plants abundant in the Trás-os-Montes and Alto
Douro region (e.g. vineyard, chestnut tree, olive tree, cherry tree, etc) are considered as potential sources
of phenolic compounds. Supercritical extraction with CO2 is used to obtain the vegetable extracts (see
Figure 1) and the effects of the operation conditions (temperature, pressure, vegetable used, etc) on
extract composition is also assessed.
Molecular recognition capabilities of the MIPs synthetized towards the polyphenols are evidenced (e.g.
packing the particles for chromatography) but hydrophilic/hydrophobic interactions are unavoidable and
a solvent gradient is needed.
Description
Keywords
Molecular imprinting Supercritical CO2 extraction Plant extracts
Citation
Gomes, Catarina; Sadoyan, Gayane; Dias, Rolando; Costa, Mário Rui (2017). Engineered polymer particles for the valorization of phenolic compounds present in mixtures obtained through supercritical extraction. In 10th Chromatography Meeting. Instituto Politécnico de Bragança