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Publication
Occurrence of polycyclic aromatic hydrocarbon metabolites in urine of portuguese firefighters
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Advisor(s)
Abstract(s)
The present work estimates occupational exposure of healthy and non-smoking Portuguese
firefighters to polycyclic aromatic hydrocarbons (PAHs) through the analysis of four urinary
metabolites (OH-PAHs): 1-hydroxyacenaphthene, 1-hydroxynaphthalene, 1-hydroxypyrene
(PAH biomarker of exposure), and 3-hydroxybenzo[a]pyrene (PAH biomarker of
carcinogenicity). Firemen from several Portuguese corporations were asked to provide urine
samples during the winter period (without exposition to fires; pre-fire season) and during the
summer season of 2014 after fires fighting. The selected OH-PAHs were extracted from urine
samples by solid-phase extraction and analyzed by high-performance liquid chromatography
with fluorescence detection. Normalization of the urinary PAH-metabolite levels was achieved
by analyzing the creatinine concentrations. 1-hydroxynaphthalene and 1-hydroxyacenaphthene
were the most abundant metabolites, followed by 1-hydroxypyrene. The metabolite 3-
hydroxybenzo[a]pyrene was not detected. Total OH-PAHs ranged from 0.02 to 4.01 μmol/mol
creatinine and between 0.55 to 8.39 μmol/mol creatinine, respectively, for non exposed and
exposed firefighters. In general, the detected concentrations of urinary PAH metabolites were
higher during the fire season than in the winter season.
Description
Keywords
Firefighters, Occupational exposure Biomonitoring Urinary pah-metabolites Liquid chromatography
Citation
Oliveira, M.; Slezakova, K.; Fernandes, Adília; Vaz, Josiana A.; Delerue-Matos, C.; Teixeira, J.P.; Pereira, M.C.; Morais, S. (2015). Occurrence of polycyclic aromatic hydrocarbon metabolites in urine of portuguese firefighters. In14th International Conference on Environmental Science and Technology (cest 2015) Will Take Place 3-5.sep.2015 Rhodes, Greece
Publisher
T.D. Lekkas