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Authors
Advisor(s)
Abstract(s)
A library of 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-1,2,3-triazoles have been investigated
for their antibacterial, antifungal and cytotoxic activities. Most of the target compounds showed
good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens.
In particular, 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-4-(4-pentylphenyl)-1,2,3-
triazole (5) was highly active against all the tested bacteria with minimal inhibitory concentrations (MICs)
ranging between 1.1 and 4.4 μM and bactericidal concentrations (MBCs) from 2.2 and 8.4 μM. The compound
1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-4-(4-bromophenyl)-1,2,3-triazole (3) showed
antifungal activity with MICs from 0.6 to 4.8 μM and minimal fungicidal concentrations (MFCs) ranging
between 1.2 and 8.9 μM. Furthermore, some of the compounds possessed moderate cytotoxicity against
human breast, lung, cervical and hepatocellular carcinoma cell lines, without showing toxicity for nontumor
liver cells. The above mentioned derivatives represent promising leads for the development of new
generation of sugar-triazole anti fungal agents.
Description
Keywords
1,2,3-Triazoles Antibacterial activity Antifungal activity Cytotoxic activity Sucrose
Pedagogical Context
Citation
Petrova, Krasimira T.; Potewar, Taterao M.; Correia-da-Silva, Paula; Barros, M. Teresa; Calhelha, Ricardo C.; Ćirić, Ana; Soković, Marina; Ferreira, Isabel C.F.R. (2015). Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives. Carbohydrate Research. ISSN 1873-426X. 417, p. 66-71
Publisher
Elsevier