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Abstract(s)
A libertação controlada de fármacos tem sido alvo de estudo, uma vez que permite controlar a dosagem de fármacos administrada, sem que chegue a um nível tóxico para o organismo.
Os sistemas de libertação controlada possuem dois objetivos fulcrais: manter constante a concentração sanguínea de um determinado fármaco no corpo humano, assegurando uma maior biodisponibilidade, reduzir os efeitos, secundários, aumentando o efeito terapêutico desejado, utilizando uma quantidade de fármaco menor.
No presente trabalho foi desenvolvida uma metodologia experimental, baseada num sistema de cromatografia líquida de alta performance (HPLC), tendo por objetivo estudar a adsorção e dessorção de cafeína no adsorvente nanoporoso MOF ZIF-8, através da realização de experiências de cromatografia frontal (etapas de saturação e de regeneração).
A partir dos resultados experimentais obtidos utilizando diferentes concentrações de cafeína e diferentes caudais, verifica-se que o adsorvente estudado MOF ZIF-8 possui boa capacidade de encapsulação. Para uma solução de cafeína com a concentração de 0.1 mg/L e a um caudal de 0.1 ml/min, o ponto de rutura ocorre em cerca de 160 minutos.
Verifica-se também que à medida que se aumenta a concentração da solução de cafeína, o tempo de rutura é superior o que mostra que o MOF tem uma boa capacidade de encapsulação.
The controlled release of drugs have been studied with the aim of controlling the dosage of administered drugs. Controlled release systems have two key objectives: maintaining a constant blood concentration of a specific drug, providing greater bioavailability and reduce side effects, thus enhancing patient compliance to treatment with fewer doses ingested. In this study was developed an experimental methodology, using a HPLC system, aiming to study the encapsulation and drug release of caffeine in MOF ZIF-8, by observing the saturation curves and regeneration of caffeine when passing through a column packed with the nanoporous material MOF ZIF-8. In view of the obtained results, it is concluded that the adsorbate MOF ZIF-8 has a good capacity for encapsulation using a caffeine solution of 0.1 mg / L at a flow rate of 0.1 ml / min, since breakthrough time occurs 160 minutes after the test started. As regards breakthrough curves, when the concentration of the caffeine solution is increased, the time to reach equilibrium also increases, so there is a better adsorption to a concentration of 0.5 mg / L of caffeine.
The controlled release of drugs have been studied with the aim of controlling the dosage of administered drugs. Controlled release systems have two key objectives: maintaining a constant blood concentration of a specific drug, providing greater bioavailability and reduce side effects, thus enhancing patient compliance to treatment with fewer doses ingested. In this study was developed an experimental methodology, using a HPLC system, aiming to study the encapsulation and drug release of caffeine in MOF ZIF-8, by observing the saturation curves and regeneration of caffeine when passing through a column packed with the nanoporous material MOF ZIF-8. In view of the obtained results, it is concluded that the adsorbate MOF ZIF-8 has a good capacity for encapsulation using a caffeine solution of 0.1 mg / L at a flow rate of 0.1 ml / min, since breakthrough time occurs 160 minutes after the test started. As regards breakthrough curves, when the concentration of the caffeine solution is increased, the time to reach equilibrium also increases, so there is a better adsorption to a concentration of 0.5 mg / L of caffeine.
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Keywords
Libertação controlada de fármacos Dessorção Cafeína MOF-ZIF-8