Ribeiro, António E.; Graça, Nuno S.; Pais, Luís S.; Rodrigues, Alírio

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Abstract(s)

Profens. or 2•aryfpropionic acids. are an important sub-class of the frequently prescribed non-steraidal anti-inflammatory drugs (NSAIDs). Some of the main primary indications for NSAIDs therapy include rheumatoid arthritis, osteoarthritis, acute gouty arthritis, dysmenorrhea and acute pain. Ketoprofen (R.S)-2-(3-benzoylphenylpropionic acid) and Flurbiprofen (R,S)-2-(2-fluoro-4- -biphenylprapionic acid) are examples of NSAIDs, both marketed as racemic mixtures.

Keywords

Profen enantiomers Chiral separation Preparative chromatography Mobile phase composition

URI

http://hdl.handle.net/10198/1160

Citation

Ribeiro, A.E.; Graça, N.S.; Pais, L.S.; Rodrigues, A.E. (2007). Preparative separation of profen enantiomers by liquid chromatography. In 5º Encontro Nacional de Cromatografia. Aveiro