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Advisor(s)
Abstract(s)
The additional TA repeat (c.-41_
-40dupTA) in the promoter of the uridine
diphosphate glucuronosyltransferase
(UGT1A1) gene is associated with a decrease
in gene transcription, a decline in
bilirubin conjugation and, therefore, with
an increase in circulating unconjugated bilirubin
(UCB) [1] . The TA repeat polymorphism
is remarkably prevalent in the Caucasian
white population and is the main
cause of Gilbert’s syndrome [1] .
Bilirubin, the key metabolic product of
hemoglobin (Hb) catabolism, has antioxidant
properties that seem to have a protective
effect in oxidative stress conditions,
such as in atherosclerosis, coronary heart
disease, inflammation, and cancer [2] .
Some studies showed that high levels of bilirubin
can be toxic to neurons in newborn
infants.
Description
Keywords
Bilirubin Redox status
Citation
Rodrigues, Carina; Rocha, Susana; Nascimento, Henrique; Vieira, Emília; Santos, Rosário; Santos-Silva, Alice; Costa, Elísio; Bronze-da-Rocha, Elsa (2013). Bilirubin levels and redox status in a young healthy population. Acta Haematologica. ISSN 0001-5792. 130:1, p. 57-60
Publisher
karger, Allschwilerstrasse