A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

Oliveira, Beatriz; Reis, Filipa S.; Sousa, Diana; Tavares, Catarina; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Santos, Tiago; Vasconcelos, M. Helena

http://hdl.handle.net/10198/10160

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Autores

Ferreira, Isabel C.F.R.

Santos, Tiago

Vasconcelos, M. Helena

Resumo(s)

Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle.

Palavras-chave

Leukemia cells Colorectal cancer Gene expression Wild mushrooms Apoptosis Proliferation

URI

http://hdl.handle.net/10198/10160

Citação

Oliveira, Marta; Reis, Filipa S.; Sousa, Diana; Tavares, Catarina; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Santos, Tiago; Vasconcelos, M. Helena (2014). A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle. Food and Function. ISSN 2042-650X. 5:7, p. 1389-1394