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Advisor(s)
Abstract(s)
To evaluate the antifungal effect of gallic acid, catechin, luteolin and
quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against
Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in
Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was
assessed through quantification of CFUs. Results: MIC values demonstrated that gallic acid
presented the highest effect against all Candida species. Catechin showed a similar effect
against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition,
gallic acid and quercetin had demonstrated only a minimal effect against Candida species
biofilms. Conclusion: Gallic acid affected the growth of the different planktonic Candida
species in all concentrations used; still, catechin showed a similar effect against C. albicans
ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin
demonstrated a slight effect against all Candida species biofilms.
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Citation
Alves, Carlos Tiago; Ferreira, Isabel C.F.R.; Barros, Lillian; Silva, Sónia; Azeredo, Joana; Oliveira, Rosário; Henriques, Mariana (2014). Antifungal activity of phenolic compounds identified in flowers from the North Eastern Portugal against Candida species. Future Microbiology. ISSN 1746-0913. 9:2, p. 139-146