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Orientador(es)
Resumo(s)
This study was designed to characterize the phenolic profile and evaluate the antibacterial, antimutagenic and antitumor activities of Veronica urticifolia Jacq. methanolic extract. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumor activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumor cell viability, while ascites volume and tumor cell count became slightly decreased, but not to a statistically significant extent. Above results indicate that V. urticifolia deserves further research into chemoprevention.
Descrição
Palavras-chave
Veronica urticifolia Phenolic profile HPLC-DAD/ESI-MS Antibacterial Antimutagenicity Ehrlich carcinoma
Contexto Educativo
Citação
Živkovic, Jelena; Barreira, João C.M.; Stojković, Dejan; Cebovic, Tatjana; Santos-Buelga, Celestino; Maksimovic, Zoran; Ferreira, Isabel C.F.R. (2014). Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq. Journal of Functional Foods. ISSN 1756-4646. 9:1, p. 192-201
Editora
Elsevier